Liquid biopsies

Genome-wide plasma DNA methylation features of metastatic prostate cancer.

Wu A, et al. The Journal of Clinical Investigation. 2020.

https://www.jci.org/articles/view/130887

Plasma Androgen Receptor Copy Number Status at Emergence of Metastatic Castration-Resistant Prostate Cancer: A Pooled Multicohort Analysis.

Jayaram A, et al. JCO Precision Oncology. 2019

https://ascopubs.org/doi/full/10.1200/PO.19.00123

Plasma Androgen Receptor and Docetaxel for Metastatic Castration-resistant Prostate Cancer.

Conteduca V, et al. European Urology. 2018.

https://www.europeanurology.com/article/S0302-2838(18)30739-5/fulltext

Androgen receptor gene status in plasma DNA associates with worse outcome on enzalutamide or abiraterone for castration-resistant prostate cancer: a multi-institution correlative biomarker study.

Conteduca V, et al. Ann Oncol. 2017.

https://academic.oup.com/annonc/article/28/7/1508/3792654

Phenotypic diversity of circulating tumour cells in patients with metastatic castration-resistant prostate cancer.

McDaniel AS, et al. BJU Int. 2017.

https://onlinelibrary.wiley.com/doi/abs/10.1111/bju.13631

Plasma AR and abiraterone-resistant prostate cancer.

Romanel A, et al. Sci Transl Med. 2015

http://stm.sciencemag.org/content/7/312/312re10.full

Androgen receptor expression in circulating tumour cells from castration resistant prostate cancer patients treated with novel endocrine agents.

Crespo M, et al. Br J Cancer. 2015

https://www.nature.com/articles/bjc201563

Tumor clone dynamics in lethal prostate cancer.

Carreira S, et al. Sci Transl Med. 2014

http://stm.sciencemag.org/content/6/254/254ra125.full

Clinical trials and international collaborations

Addition of docetaxel to hormonal therapy in low- and high-burden metastatic hormone sensitive prostate cancer: long-term survival results from the STAMPEDE trial.

Clarke N, et al. Ann. Oncol. 2019

https://www.sciencedirect.com/science/article/pii/S0923753420325527

Assessment of the Safety of Glucocorticoid Regimens in Combination With Abiraterone Acetate: A Randomized, Open-Label Phase 2 Study.

Attard G, et al. JAMA Oncology. 2019

https://jamanetwork.com/journals/jamaoncology/fullarticle/2737089

Sequencing of agents in castration-resistant prostate cancer.

Lorente D, et al. Lancet Oncol. 2015

https://www.sciencedirect.com/science/article/pii/S1470204515700331?via%3Dihub

Improvements in radiographic progression-free survival stratified by ERG gene status in metastatic castration-resistant prostate cancer patients treated with abiraterone acetate.

Attard G, et al. Clin Cancer Res. 2015

http://clincancerres.aacrjournals.org/content/21/7/1621.long

Interactions of abiraterone, eplerenone, and prednisolone with wild-type and mutant androgen receptor: a rationale for increasing abiraterone exposure or combining with MDV3100.

Richards J, et al. Cancer Res. 2012

http://cancerres.aacrjournals.org/content/72/9/2176

STRATOSPHERE

P - 182 Tumour Infiltrating Lymphocytes assessment in the STAMPEDE cohort: association of brisk inflammation with high grade histology.

Mendes L, et al. EACR-AACR-ASPIC Tum Microenvironment 2020

http://nwm.covr.be/EAA2020abstracts/data/HtmlApp/main.html#0

153 Multiregion expression profiling of prostate cancer from men randomized in the STAMPEDE trial: Stage I results of a multistage biomarker analysis.

Grist E, et al. J Clin Oncol 2020

https://meetinglibrary.asco.org/record/183430/abstract

39 Copy number profiling of STAMPEDE trial patients to improve targeting of existing therapies for advanced hormone-sensitive prostate cancer.

Grist E, et al. EACR Cancer Genomics Conference 2019

https://www.eacr.org/user_uploads/files/CG19%20A5%20Programme%20Book%20ONLINE.pdf

88 Whole genome expression analysis of diagnostic patient samples enrolled in the STAMPEDE clinical trial in advanced prostate cancer.

Parry M, et al. EACR Cancer Genomics Conference 2019

https://www.eacr.org/user_uploads/files/CG19%20A5%20Programme%20Book%20ONLINE.pdf

29P - Implementing molecular characterisation of prostate cancer tissue from patients recruited to the multi-centre STAMPEDE trial: The STRATOSPHERE consortium

Grist E, et al. Ann. Oncol. 2018

https://www.sciencedirect.com/science/article/pii/S0923753419323804

 

Editorials and Reviews

Plasma DNA Analysis in Prostate Cancer: Opportunities for Improving Clinical Management.

Wu A, Attard G. Clin Chem 2019.

https://academic.oup.com/clinchem/article/65/1/100/5607912

Plasma DNA and Metastatic Castration-Resistant Prostate Cancer: The Odyssey to a Clinical Biomarker Test.

Jayaram A, Wetterskog D, Attard G, Cancer Discov. 2018.

http://cancerdiscovery.aacrjournals.org/content/8/4/392.long

Selected publications

Treatment Resistance Group, UCL Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6DD, UK

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